CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.
Identifieur interne : 000420 ( Main/Exploration ); précédent : 000419; suivant : 000421CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.
Auteurs : Christian Gytz Ammitzb Ll ; Rudi Steffensen ; Martin B Gsted ; Kim H Rslev-Petersen ; Merete L. Hetland ; Peter Junker ; Julia S. Johansen ; Jan P Denphant ; Mikkel Stergaard ; Torkell Ellingsen ; Kristian Stengaard-PedersenSource :
- Arthritis research & therapy ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (genetics), C-Reactive Protein (genetics), C-Reactive Protein (metabolism), Cohort Studies, Female, Gene Frequency, Genotype, Haplotypes, Humans, Linear Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , genetics : C-Reactive Protein.
- chemical , metabolism : C-Reactive Protein.
- chemical , therapeutic use : Antirheumatic Agents.
- blood : Arthritis, Rheumatoid.
- drug therapy : Arthritis, Rheumatoid.
- genetics : Arthritis, Rheumatoid.
- Adult, Aged, Cohort Studies, Female, Gene Frequency, Genotype, Haplotypes, Humans, Linear Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Severity of Illness Index, Treatment Outcome.
Abstract
Single-nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to proinflammatory stimuli. Previous reports suggest that these effects may have an impact on clinical decision-making tools based on CRP, such as the Disease Activity Score in 28 joints (DAS28). We aimed to investigate the possible association between seven CRP SNPs, their haplotypes and the serum levels of CRP, as well as DAS28 scores, in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment.
DOI: 10.1186/s13075-014-0475-3
PubMed: 25359432
Affiliations:
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Le document en format XML
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Hetland</name></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name></author><author><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1186/s13075-014-0475-3</idno><idno type="RBID">pubmed:25359432</idno><idno type="pmid">25359432</idno><idno type="wicri:Area/PubMed/Corpus">000135</idno><idno type="wicri:Area/PubMed/Curation">000135</idno><idno type="wicri:Area/PubMed/Checkpoint">000185</idno><idno type="wicri:Area/Ncbi/Merge">000C61</idno><idno type="wicri:Area/Ncbi/Curation">000C61</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C61</idno><idno type="wicri:Area/Main/Merge">000409</idno><idno type="wicri:Area/Main/Curation">000420</idno><idno type="wicri:Area/Main/Exploration">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.</title><author><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name></author><author><name sortKey="Steffensen, Rudi" sort="Steffensen, Rudi" uniqKey="Steffensen R" first="Rudi" last="Steffensen">Rudi Steffensen</name></author><author><name sortKey="B Gsted, Martin" sort="B Gsted, Martin" uniqKey="B Gsted M" first="Martin" last="B Gsted">Martin B Gsted</name></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name></author><author><name sortKey="Hetland, Merete L" sort="Hetland, Merete L" uniqKey="Hetland M" first="Merete L" last="Hetland">Merete L. Hetland</name></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name></author><author><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></author></analytic><series><title level="j">Arthritis research & therapy</title><idno type="e-ISSN">1478-6362</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (blood)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (genetics)</term><term>C-Reactive Protein (genetics)</term><term>C-Reactive Protein (metabolism)</term><term>Cohort Studies</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Single-nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to proinflammatory stimuli. Previous reports suggest that these effects may have an impact on clinical decision-making tools based on CRP, such as the Disease Activity Score in 28 joints (DAS28). We aimed to investigate the possible association between seven CRP SNPs, their haplotypes and the serum levels of CRP, as well as DAS28 scores, in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name><name sortKey="B Gsted, Martin" sort="B Gsted, Martin" uniqKey="B Gsted M" first="Martin" last="B Gsted">Martin B Gsted</name><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><name sortKey="Hetland, Merete L" sort="Hetland, Merete L" uniqKey="Hetland M" first="Merete L" last="Hetland">Merete L. Hetland</name><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name><name sortKey="Steffensen, Rudi" sort="Steffensen, Rudi" uniqKey="Steffensen R" first="Rudi" last="Steffensen">Rudi Steffensen</name><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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